Further Development of a Test Method for the Assessment of the Acute Inhalation Toxicity of Combustion Products.
Further Development of a Test Method for the Assessment
of the Acute Inhalation Toxicity of Combustion Products.
Levin, B. C.; Fowell, A. J.; Birky, M. M.; Paabo, M.;
Stolte, A.; Malek, D.
NBSIR 82-2532; 143 p. June 1982.
Available from: National Technical Information Service
Order number: PB82-217886
combustion products; flaming combustion; inhalation;
toxicity test methods; toxicity; inhalation toxicity
This report describes the development of a test method
for the assessment of acute inhalation toxicity of
combustion products of materials. The procedure is
primarily intended for research and screening purposes.
It provides: 1) a method for determining, under flaming
and non-flaming conditions, the LC50 (the concentration
of combustion products which causes 50% lethality in the
test animals (rats) exposed for 30 minutes and observed
for 14 days following exposure); 2) an optional
procedure to examine materials which rapidly produce
combustion products which cause death of test animals
within a 10 minute exposure and a 14 day post-exposure
observation period; and 3) a description of analytical
and physiological measurements which can provide more
detailed information on the nature of the toxic effects
of combustion products. Limitations of the test method
are identified and future work to address them is
proposed. The participation through the direct exchange
of technical information of organizations representing
academic, industry, and other agencies of the United
States Government is acknowledged.